摘要
目的 探讨耳穴压丸辅助奥施康定联合阿普唑仑对恶性肿瘤患者心理与生存质量影响。方法 收集我院32例癌痛患者，随机分为两组：对照组（n=16）和观察组（n=16）；观察两组患者心理状态和NRS、PSQI评分，并进行比较分析。结果 治疗后，观察组各项指标优于对照组，差异具有统计学意义（P<0.05）。结论 耳穴压丸辅助奥施康定联合阿普唑仑，有助于辅助提高治疗效果、改善焦虑、睡眠障碍、疼痛恐惧、抑郁等心理状态，提高患者生活质量，值得推广。
关键词： 耳穴压丸；奥施康定；阿普唑仑；癌痛
Abstract
Objective: To investigate the effect of auricular acupoint BOLus combined with OxyContin and alprazolam on psychology and quality of life in patients with malignant tumor. Methods: 32 patients cancer pain were randomly divided into two groups：Control group (n=16)and Observation group (n=16); The psychological state, NRS and PSQI scores of the two groups were observed and compared. Results: After treatment, the indexes of the observation group were better than those of the control group, and the difference was makely significant (P<0.05). Conclusion : Auricular acupoint bolus combined with OxyContin and alprazolam can help to improve the therapeutic effect, improve anxiety, sleep disorders, pain, fear, depression and other psychological states, and improve the quality of life of patients, which is worthy of promotion.
Key words： Auricular point bolus; Oxycontin; Alprazolam; Pain
参考文献 References
[1] 杨之洵,曾红梅,郑荣寿,等.大气污染与主要癌症相关性研究进展[J].中华流行病学杂志,2018,39(04):532-535.
[2] Vrinten C , Boniface D , Lo S H , et al. Does psychosocial stress exacerbate avoidant responses to cancer information in those who are afraid of cancer? A population-based survey among older adults in England[J]. Psychology & Health, 2018, 33(1):117-129.
[3] 郭珺,吕静,刘波,等.中重度癌痛盐酸羟考酮缓释片治疗剂量调整临床研究[J].中华肿瘤防治杂志,2017, 24(18): 1319-1322.
[4] Sessler NE, Downing JM, Kale H, et al. Reductions in reported deaths following the introduction of extended- release oxycodone (OxyContin) with an abuse-deterrent formulation[J]. Pharmacoepidemiology & Drug Safety. 2014; 23 (12) :1238-46.
[5] Schmidt-Hansen M, Bennett MI, Arnold S, et al. Oxycodone for cancer-related pain[J]. Cochrane Database Syst Rev. 2015;2(2):CD003870.
[6] 金慧, 胡燕, 朱燕舞, 等. 不规范使用盐酸羟考酮缓释片致成瘾的诊治体会[J]. 中国现代应用药学. 2019 (15):1947-50.
[7] 冉霄. 针刺结合耳穴压丸法配合奥施康定治疗癌性疼痛的疗效对比研究[D].湖北中医药大学,2017.
[8] Paice J A, Mulvey M, Bennett M, et al. AAPT Diagnostic Criteria for Chronic Cancer Pain Conditions.[J]. Churchill Livingstone, 2017;18(3): 233-246.
[9] JM Esparza-Miñana. Diagnosis and medical treatment of breakthrough pain[J]. Medicina Clinica, 2018, 150(3):114.
[10] 叶林生.盐酸羟考酮缓释片联合盐酸吗啡片在癌痛滴定治疗中的应用价值体会[J].中国实用医药,2019, 14(22):68-70.
[11] 张红霞,李炜,许学萍.盐酸羟考酮缓释片对老年晚期非小细胞肺癌患者镇痛效果及炎症因子水平的影响[J].海军医学杂志,2019,40(03):237-240.
[12] 李琳.盐酸羟考酮缓释片初始滴定治疗老年癌痛的疗效观察[J].山西医药杂志,2017,46(06):684-686.
[13] 陈润,曾睿芳,方平,等.耳穴压豆联合盐酸羟考酮缓释片对癌性疼痛患者疼痛爆发次数及PPI与KPS评分的影响[J].西部医学,2021,33(11):1683-1686.
[14] 李荣,张利.耳穴压丸在癌性疼痛患者中的应用效果[J].航空航天医学杂志,2019,30(07):895-896.
[15] 贺晓丹,陈实.耳穴压丸联合吗啡治疗中重度癌痛临终关怀患者的疗效探讨[J].中国社区医师,2019,35(24):90.