摘要
糖尿病酮症酸中毒(DKA)是1型糖尿病中胰岛素缺乏的最终结果。高水平的反调节激素导致生酮增强和“酮体”释放到循环中,它们解离释放氢离子并导致酸中毒。小儿DKA发病紧急,严重者甚至危及生命,需要快速识别和进行有组织的治疗。积极的护理可以帮助DKA患儿迅速脱离危险,加快患儿的康复,现就小儿DKA的临床表现、治疗目标、并发症的预防和护理工作进行总结,旨在对进一步促进小儿DKA的临床治疗提供理论依据。
关键词: 糖尿病酮症酸中毒;儿童;治疗;护理
Abstract
Diabetic ketoacidosis (DKA) is the end result of insulin deficiency in type 1 diabetes. High levels of counter-regulatory hormones lead to enhanced ketogenesis and the release of "ketone bodies" into the circulation, which dissociate to release hydrogen ions and cause acidosis. Pediatric DKA has an urgent and even life-threatening onset and requires rapid recognition and organized treatment. Active nursing care can help children with DKA out of danger quickly and speed up their recovery. The clinical manifestations, treatment goals, prevention of complications and nursing care of pediatric DKA are summarized here to provide a theoretical basis for further promoting the clinical treatment of pediatric DKA.
Key words: Diabetic ketoacidosis; children; treatment; nursing
参考文献 References
[1] 赵亮. 糖尿病酮症酸中毒急性腹痛的发病机制与急腹症的鉴别要点及诊疗体会分析[J]. 糖尿病新世界, 2020,23(9):183-185.
[2] 罗燕飞, 阿皮耶提•麦麦提图尔荪, 玛依拉•阿不都热依木, 等. 316例儿童1型糖尿病临床特点及酮症酸中毒危险因素分析[J]. 新疆医学, 2022,52(1):18-21, 17.
[3] 米佳, 曹棨. 儿童糖尿病酮症酸中毒的临床特征与治疗进展[J]. 中国综合临床, 2014,30(2):220-222.
[4] 唐发娟, 陈琳, 肖东琼. 儿童糖尿病酮症酸中毒并发脑水肿的研究进展[J]. 预防医学, 2021,33(06):579-582.
[5] Miszczuk K, Mroczek-Wacinska J, Piekarski R, et al. Ventricular bigeminy and trigeminy caused by hypophosphataemia during diabetic ketoacidosis treatment: a case report[J]. Ital J Pediatr, 2019,45(1):42.
[6] 唐发娟, 陈琳, 肖东琼. 儿童糖尿病酮症酸中毒并发脑水肿的研究进展[J]. 预防医学, 2021,33(06):579-582.
[7] Douros A, Lix L M, Fralick M, et al. Sodium-Glucose Cotransporter-2 Inhibitors and the Risk for Diabetic Ketoacidosis: A Multicenter Cohort Study[J]. Ann Intern Med, 2020,173(6):417-425.
[8] 王颐. 1例急性脑出血合并酮症酸中毒患者的护理体会: 第十四届中国医师协会神经外科医师年会[C], 中国浙江杭州, 2019.
[9] 李子惠, 李辉. 心理护理干预对ICU糖尿病酮症酸中毒患者护理效果的对比分析[J]. 心理月刊, 2020, 15(23): 18-19.
[10] 冯玉娇. 针对性护理对糖尿病酮症酸中毒患儿疗效与中毒症状改善的影响研究[J]. 糖尿病新世界, 2022, 25(14):98-101.
[11] 闫玉群. 综合护理干预对胰岛素泵治疗儿童Ⅰ型糖尿病酮症酸中毒疗效的影响[J]. 黑龙江中医药, 2021, 50(06):417-418.
[12] 刘艳. 小儿糖尿病酮症酸中毒临床急救措施及护理分析[J]. 糖尿病新世界, 2015, 35(3):1.
[13] 韩丽丽. 综合护理在糖尿病酮症酸中毒病人中的应用[J]. 护理研究:下旬版, 2016(7):2.
[14] 王丹. 34例小儿糖尿病酮症酸中毒抢救及护理措施[J]. 糖尿病新世界, 2015, 35(14):3.
[15] 柳王芳. 小儿糖尿病酮症酸中毒临床急救及护理对策[J]. 世界最新医学信息文摘, 2016.