摘要
目的 探讨镇静治疗辅助吸痰操作对于重型颅脑损伤患者的颅内压的（intracranial pressure, ICP）影响。方法 根据本次研究的纳入标准，纳入96例重型颅脑损伤的患者，分为A组（48例）和B组（48例），A组患者在接受吸痰操作中予以异丙酚镇静治疗辅助，B组无镇静辅助，记录所有患者每次吸痰前2min、吸痰瞬间及吸痰后2min等3个时段点的ICP值以及其吸痰的时间间隔（Ts）与吸痰频率（Fs），最终将所有数据进行统计学分析。结果 通过ICP 检测仪发现A组内患者ICP在吸痰前、吸痰时以及吸痰后的比较无统计学差异（P＞0.05），而B组患者的ICP在吸痰过程大幅度升高（P＜0.01）。A组患者Ts明显长于B组，B组患者的Fs明显高于A组，统计学分析结果显示两组患者在Ts与Fs数据的比较上均具有显著的统计学差异（P＜0.01）。结论 镇静治疗辅助下的，可以有效改善重型颅脑损伤患者在吸痰操作中的ICP的大幅度升高，也利于更高效的清除呼吸道中的痰液，改善肺部功能。
关键词： 颅内压；异丙酚；镇静；痰液
Abstract
Objective To investigate the effect of sedation-assisted sputum suction on intracranial pressure (ICP) in patients with severe traumatic brain injury. Methods According to the inclusion criteria of this study, 96 patients with severe craniocerebral injury were included and divided into group A (48 cases) and group B (48 cases). The patients in group A were given propofol sedation during the sputum suction operation In group B, there was no sedative assistance, and the ICP values of all patients at 2 minutes before each suction, at the moment of suction, and 2 minutes after suction, as well as the time interval of suction (Ts) and frequency of suction (Fs) were recorded. ), and finally all the data were analyzed statistically. Results Through the ICP detector, it was found that the ICP of patients in group A had no statistical difference before, during and after suctioning (P>0.05), while the ICP of patients in group B increased significantly during suctioning ( P<0.01). The Ts of patients in group A was significantly longer than that of group B, and the Fs of patients in group B was significantly higher than that of group A. Statistical analysis results showed that there were significant statistical differences in the comparison of Ts and Fs data between the two groups (P<0.01). Conclusion With the aid of sedation therapy, it can effectively improve the significant increase of ICP during sputum suction operation in patients with severe traumatic brain injury, and it is also conducive to more efficient removal of sputum in the respiratory tract and improvement of lung function.
Key words： Intracranial pressure; Propofol; Calm; sputum
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