A case of drug-induced anaphylactic shock caused by magnesium isoglycyrrhizinate injection
异甘草酸镁注射液致药源性过敏性休克一例

摘要

过敏性休克是一种发作迅速、严重时可危及生命的全身性反应，致敏原侵入机体刺激肥大细胞或者嗜碱粒细胞脱颗粒导致组胺、类胰蛋白酶、白细胞介素、一氧化氮和血小板活化因子（Platelet-Activating Factor，PAF）等大量炎症递质释放，这些炎症递质导致全身性毛细血管扩张，血浆外渗，有效血容量下降，最终导致过敏性休克[1]。异甘草酸镁注射液作为一种保肝药物，广泛应用于临床。然而，其引发的药源性过敏性休克病例逐渐增多，对患者的生命安全构成威胁。本文从护理角度出发，探讨异甘草酸镁注射液致药源性过敏性休克的护理方法。创新点在于提出了一种新型的护理方法，该方法通过提高护理人员的专业素养、加强患者健康教育、实施早期预防措施和及时处理等环节，有效地降低了异甘草酸镁注射液致药源性过敏性休克的发生率和死亡率。本文旨在为临床药源性过敏性休克护理提供有益的参考，提高患者的用药安全性和生活质量。

Abstract

Anaphylactic shock is a rapid, severe and life-threatening systemic reaction in which allergens invade the body and stimulate mast cells or basophilic granulocytes to degranulate, resulting in histamine, trypsinoid, interleukin, nitric oxide and platelet-activating factor, A large number of inflammatory transmitters such as PAF are released, which lead to systemic telangiectasia, plasma extravasation, and decrease of effective blood volume, eventually leading to anaphylactic shock [1]. Magnesium isoglycyrrhizinate injection is widely used in clinic as a liver protection drug. However, the cases of drug-induced anaphylactic shock caused by it are increasing gradually, which poses a threat to the life safety of patients. From the nursing point of view, this paper discusses the nursing method of magnesium isoglycyrrhizinate injection induced by drug induced anaphylactic shock. The innovation point is that a new nursing method is proposed which can effectively reduce the incidence and mortality of drug-induced anaphylactic shock caused by magnesium isoglycyrrhizinate injection by improving the professional quality of nursing staff, strengthening the health education of patients, implementing early preventive measures and timely treatment. The purpose of this paper is to provide useful reference for the nursing care of patients with drug-induced anaphylactic shock, and to improve the safety of medication and quality of life of patients.