摘要
总结1例体外膜肺氧合(ECMO)救治免疫检查点抑制剂(ICIs)相关性心肌炎致持续电风暴患者的护理。护理要点:组建多学科应急小组,明确分工;及时除颤,配合药物治疗维持心率,全程心电监护,启动静脉-动脉体外膜肺氧合(VA-ECMO);做好血浆置换与连续性肾脏替代治疗(CRRT)护理,预防有创操作感染;ECMO运行时,实施个性化抗凝管理,防控感染,并提供营养支持与心理支持。经过治疗与精细护理,患者入院23天后出院。
关键词: 体外膜肺氧合;免疫检查点抑制剂;心肌炎;电风暴
Abstract
Summarize the nursing care of a patient with persistent electrical storm caused by immune checkpoint inhibitors(ICIs)-related myocarditis treated by extracorporeal membrane oxygenation(ECMO). Key points of nursing: Form a multi-disciplinary emergency response team and clearly define responsibilities. Timely defibrillation, combined with drug treatment to maintain heart rate, full-course electrocardiogram monitoring, and initiation of VA-ECMO. Ensure proper plasma exchange and continuous renal replacement therapy(CRRT) care to prevent infections from invasive procedures. During the operation of ECMO, personalized anticoagulation management is implemented to prevent and control infections, and nutritional and psychological support is provided.
Key words: Extracorporeal membrane oxygenation; Immune checkpoint inhibitors; Myocarditis; Electrical storm
参考文献 References
[1] 王妍,陈慧勇,林瑾仪,等.免疫检查点抑制剂相关心肌炎临床诊疗实施建议[J].中国临床医学,2023,30(2):368-390.
[2] Zhuang Y,An Q,Wang F,et al.The role of circulating biomarkers in predicting the 30-day mortality of immune checkpoint inhibitors-related myocarditis: a retrospective cohort study[J].Intern Emerg Med,2024,19(2):377-389.
[3] 沈菲,杨芳,华雨,等.1例重症爆发性心肌炎发生电风暴及应用体外膜肺氧合的护理报告[J].护理实践与研究, 2021, 18(12):1893-1895.
[4] 张豪,王艳玲,范振兴,等.ECMO联合IABP、CRRT成功救治暴发性心肌炎合并心脏电风暴1例[J].临床心血管病杂志,2024,40(12):1032-1034.
[5] 赵玉英,宫智,郭晓影,等.表现为双向性室性心动过速的免疫检查点抑制剂相关性心肌炎一例[J].中华老年心脑血管病杂志,2023,25(12):1389-1390.
[6] He W,Zhou L,Xu K,et al.Immunopathogenesis and immunomodulatory therapy for myocarditis[J].Sci China Life Sci,2023,66(9):2112-2137.
[7] 施姣姣,吴楠,陈红武,等.急性心肌梗死后电风暴诊治二例[J].中国循环杂志,2023,38(10):1075-1078.
[8] 刘丹丹,孙君香,张俊,等.1例心脏手术后突发电风暴患者行星状神经节阻滞术的护理[J].中华护理杂志,2024, 59(22):2781-2784.