Clinical efficacy of continuous renal replacement therapy in sepsis patients and its effect on bloodstream infections
连续性肾脏替代治疗脓毒症患者的临床疗效及对血流感染的作用分析

摘要

目的 探讨连续性肾脏替代治疗脓毒症患者的临床疗效及对血流感染的作用。方法 研究选取2025年1月-2026年1月在本医院接受治疗的120例脓毒症患者作为研究样本，采取随机数字表法将所有患者进行分组，即对照组采取常规治疗方式（60例）与观察组采取连续性肾脏替代治疗方式（60例），以此比较两组患者的ICU住院时间、总住院时间、器官功能障碍改善情况、临床疗效、血流感染发生率。结果 观察组患者的ICU住院时间和总住院时间短于对照组，差异具有统计学意义（P<0.05）；观察组患者器官功能障碍改善情况更优秀，差异具有统计学意义（P<0.05）；观察组患者的临床疗效优于对照组，差异具有统计学意义（P<0.05）；观察组患者的血流感染发生率低于对照组，差异具有统计学意义（P<0.05）。结论 连续性肾脏替代治疗脓毒症患者能够有效缩短患者ICU住院时间和总住院时间，帮助患者改善器官功能障碍，降低血流感染发生率，提高临床疗效，值得进一步推广应用。

Abstract

Objective To investigate the clinical efficacy of continuous renal replacement therapy in sepsis patients and its effect on bloodstream infections.
Methods A total of 120 sepsis patients who received treatment in our hospital from January 2025 to January 2026 were selected as the study sample. The random number table method was used to divide all patients into two groups: the control group received conventional treatment (60 cases) and the observation group received continuous renal replacement therapy (60 cases). The ICU stay, total hospital stay, improvement of organ dysfunction, clinical efficacy, and incidence of bloodstream infections were compared between the two groups of patients.
Results The ICU hospitalization time and total hospitalization time of the observation group patients were shorter than those of the control group, and the difference was statistically significant (P<0.05); The observation group showed better improvement in organ dysfunction, with a statistically significant difference (P<0.05); The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P<0.05); The incidence of bloodstream infection in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05).
Conclusion   Continuous renal replacement therapy can effectively shorten the ICU and total hospitalization time of sepsis patients, help improve organ dysfunction, reduce the incidence of bloodstream infections, and enhance clinical efficacy. It is worth further promoting and applying.