摘要
目的 分析慢性阻塞性肺疾病患者在急性加重期的感染病原菌分布情况，以及集体免疫功能的变化情况检测分析，并对存在的相关危险因素进行探讨。方法 选取时间段为2018.1月~2020.1月期间，于我院呼吸内科中接受诊治的慢阻肺急性加重期患者70例，将其作为本次实验的研究对象，分析慢阻肺急性加重期患者的肺部感染病原菌分布情况以及机体免疫球蛋白水平。结果 分析70例慢阻肺急性加重期患者的病原菌本部情况，其中构成比占据前五位的为流感嗜血杆菌、金黄色葡萄球菌、肺炎克雷伯菌、肺炎链球菌、铜绿假单胞菌，其构成比分别为（20.00%）、（20.00%）、（17.57%）、（15.71%）、（12.85%）。此外，对比三组患者的机体免疫球蛋白水平，均呈现出持续下降的趋势，且数据间差异明显，（P＜0.05），存在统计学意义。结论 对于慢阻肺急性加重期患者来说，其肺部感染病原菌分布情况以及机体免疫球蛋白水平是直接关系到疾病的发展严重情况的，且对于可能造成疾病加重的相关危险因素，需要制定切实有效的措施进行防范和控制，以保障患者的身体质量。
关键词： 慢阻肺急性加重期；感染病原菌分布情况；机体免疫功能检测
Abstract
Objective: To analyze the distribution of infectious pathogens in patients with chronic obstructive pulmonary disease during the acute exacerbation period, as well as the detection and analysis of changes in collective immune function, and discuss the related risk factors. Methods: 70 patients with acute exacerbation of COPD who were diagnosed and treated in the Department of Respiratory Medicine of our hospital during the period from January 2018 to January 2020 were selected as the research object of this experiment to analyze patients with acute exacerbation of COPD .The distribution of pathogenic bacteria in lung infection and the level of immune globulin in the body. Results: The pathogenic bacteria in 70 patients with acute exacerbation of COPD were analyzed. The top five were Haemophilus influenzae, Staphylococcus aureus, Klebsiella pneumoniae, Streptococcus pneumoniae and Pseudomonas aeruginosa. The composition ratio of bacteria is (20.00%), (20.00%), (17.57%), (15.71%), (12.85%). In addition, comparing the body immunoglobulin levels of the three groups of patients, they all showed a continuous downward trend, and the difference between the data was significant (P <0.05), which was statistically significant. Conclusion : For patients with acute exacerbation of COPD, the distribution of pathogenic bacteria in the lung infection and the level of immune globulin in the body are directly related to the serious development of the disease, and the relevant risk factors that may cause the disease need to be formulated effective and effective measures to prevent and control to ensure the patient's physical quality.
Key words： acute exacerbation of COPD; distribution of infectious pathogens; detection of immune function
参考文献 References
[1]
[2]
[3]
[4]
[5]
[6]
[7]
[8]
[9]