The Value of Inflammatory Indexes in Diagnosing Infectious Diseases with Fever
炎性指标诊断发热待查感染性疾病的价值

摘要

目的 分析炎性指标在诊断发热待查感染性疾病的应用价值。方法 选取2018年5月至2020年5月我院收治的发热待查患者240例，对所有患者的临床资料展开回顾性分析，以此研究炎性指标在诊断发热待查感染性疾病中的具体应用。结果 通过对比发现，细菌感染患者的ESR水平（62.5±33.2）mm/h，明显高于真菌感染患者的ESR水平（26.5±32.1）mm/h，具有统计学意义（P＜0.05）。细菌感染患者的CRP水平（54.7±43.7）mg/L，分别与病毒感染患者的CRP水平（32.2±31.6）mg/L和真菌感染患者的CRP水平（17.3±20.1）mg/L，存在着明显的差异，具有统计学意义（P＜0.05）。对比三组感染性疾病患者的WBC和PCT，均未发现任何明显差异，不具备统计学意义（P＞0.05）。而将不同细菌感染疾病患者的WBC、ESR、CRP及PCT进行对比，也未发现任何明显差异，不具备统计学意义（P＞0.05）。利用ROC曲线计算可得，用CRP数值鉴别细菌感染与病毒感染的灵敏度为77.2％，阈值为84.6mg/L。而采用ESR鉴别细菌感染与真菌感染时的灵敏度为84.5％，阈值为46mm/h。结论 WBC水平对发热待查患者的感染性疾病鉴别工作意义不大，但CRP和ESR水平对该项工作具有重要的临床意义。若利用PCT水平予以鉴别，需谨慎解读数据，避免误判的现象发生。

Abstract

Objective: To analyze the application value of inflammatory indicators in the diagnosis of fever and infectious diseases under investigation.
Methods: A total of 240 patients with fever to be examined in our hospital from May 2018 to May 2020 were selected, and the clinical data of all patients were retrospectively analyzed to study the role of inflammatory indicators in the diagnosis of fever and infectious diseases to be examined. application.
Results: Through comparison, it was found that the ESR level of patients with bacterial infection (62.5±33.2) mm/h was significantly higher than that of patients with fungal infection (26.5±32.1) mm/h, which was statistically significant (P<0.05). The CRP level of patients with bacterial infection (54.7±43.7) mg/L is significantly different from the CRP level of patients with virus infection (32.2±31.6) mg/L and the CRP level of patients with fungal infection (17.3±20.1) mg/L. The difference was statistically significant (P<0.05). Comparing the WBC and PCT of the three groups of patients with infectious diseases, no significant difference was found, which was not statistically significant (P>0.05). However, comparing WBC, ESR, CRP and PCT of patients with different bacterial infections, no significant difference was found, which was not statistically significant (P>0.05). Using ROC curve calculation, the sensitivity of using CRP value to distinguish bacterial infection and virus infection is 77.2%, and the threshold is 84.6 mg/L. The sensitivity of ESR to distinguish bacterial infection from fungal infection was 84.5%, and the threshold was 46mm/h.
Conclusion  : WBC level is of little significance for the identification of infectious diseases in patients with fever under investigation, but CRP and ESR levels have important clinical significance for this work. If the PCT level is used for identification, the data must be interpreted carefully to avoid misjudgment.